Adomeds

S-Adenosyl-L-Methionine (SAM-e)

S-Adenosyl-L-Methionine (SAM-e), Oral Capsules 400mg

Other ingredients:
Microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate.

Indication:
Mild depression, major depressive disorder (MDD), Decreased libido,erectile dysfunctions, mood disorders, PMS, Post menopause, fibromyalgia, MS.

Dosing:
400mg ADOMEDS® capsule can be used twice per day. Depending on clinical response, ADOMEDS dose can be increased to 1600 mg per day. ADOMEDS® should be taken on empty stomach, i.e., one hour before or two hours after meals. It is better to take ADOMEDS in two or three divided doses.

Contraindication:
Allergic to any ingredient in ADOMEDS. Should be avoided in patients using Levodopa.

Side effects:
Side effects that have been reported may include mild gastrointestinal upset (e.g. stomach pain, nausea, diarrhea, and flatulence), anxiety, hypomania and insomnia. Due to above facts, you should not take this supplement at night.

Pregnancy & Lactation:
ADOMEDS should only be used by pregnant woman under a physician’s supervision. Nursing mothers should avoid SAM-e supplementation.

Warning:
Patients with bipolar disorder should not take ADOMEDS without concomitant administration of mood stabilizers coupled with clinical monitoring.

ADOMEDS is a product of Ashbal Chemi using API (Adomix) by Gnosis, Italy

What is ADOMEDS?

ADOMEDS® is S-Adenosyl-L-Methionine (SAM-e) containing product that is a major methyl donor in the brain, and is involved in the synthesis of hormones and neurotransmitters.

Why ADOMEDS?

• Can be used by patients with mildly symptomatic depression and the ones diagnosed with MDD. • Can be used as an adjunctive agent along with conventional antidepressants for MDD. • Beneficial for treatment-resistant patients or the ones who are unable to tolerate the side effects. • Promotes sexual function such as libido and erection. • Reduces sexual dysfunction caused by antidepressants. • Shows promise in treatment of neuropsychiatric diseases, such as fibromyalgia. • Shows positive response on mood in neurological disorders, such as epilepsy. • Helps CNS (re-)myelination in neurodegenerative diseases, such as (MS). • Generally well-tolerated with less adverse effects and rapid onset of action.

Mechanism of action

• Essential for synthesis of serotonin, dopamine, and norepinephrine. • Helps to restore cellular membrane fluidity by phospholipid methylation. • Improves neurotransmission by increasing the number of adrenergic receptors. • Improves dopaminergic activity.

Literature Review

There are several studies showing evidence of antidepressant effects of SAM-e with fewer side effects

The effect of SAM-e used as a neutraceutical in refractory depression.

Changes in HAM-D scores of SAM-e and imipramine.

The number of patients experiencing adverse events caused by SAM-e and imipramine.

References

J Clin Psychiatry; 70(suppl 5), p: 18-22. Ann Gen Psychiatry; 19:50, p: 1-7. Neurotherapeutics; 15, p: 156-175. Am J Clin Nutr; 76 (suppl):1172S-6S. Am J Psychiatry ; 167, p: 942–948. European Psychiatry; 27, p: 451-454. Current Issues in Molecular Biology; 44, p:3335-3350. Current therapeutic research. 1;53(2), p:222-9. Drugs; 48, p: 137–152. Neuroscience Letters 562, p: 75-78. Kaplan & Sadock’s, Textbook of Psychiatry, 9th ed. Kaplan & Sadock’s, Textbook of Psychiatry, 10th ed. Kaplan & Sadock’s, Textbook of Psychiatry, 12th ed. Psychother Psychosom. 59(1), p:34-40. International clinical psychopharmacology, 2(2), p: 97-102. Original Internist, p:91.